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Abstract B85: In vivo radiosensitizer effect of the HDAC

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More articles from Epigenetic Targets | Molecular Cancer Therapeuti

AACR Journals Blood Cancer Discovery Cancer Discovery Cancer Epidemiology, Biomarkers & Prevention Cancer Immunology Research Cancer Prevention Research Cancer Research Clinical Cancer Research Molecular Cancer Research Molecular Cancer ...

Radiosensitization by SAHA in Experimental Colorectal Carcinoma Models-In Vivo Effects and Relevance of Histone Acetylation Status (Journal .

Radiosensitization by SAHA in Experimental Colorectal Carcinoma Models-In Vivo Effects and Relevance of Histone Acetylation Status ...

Abstract B85: In vivo radiosensitizer effect of the HDAC inhibitor S78454 on orthotopic human glioblastoma. | Molecular Cancer Therapeuti

Abstract Glioblastoma is an aggressive primary brain tumor with poor outcome, despite a treatment associating surgery and radiotherapy combined with temozolomide. Recent data have shown an in vitro synergy of the HDAC inhibitor S78454 (also called PCI-24781 ...

The histone deacetylase inhibitor PCI-24781 as a putative radiosensitizer in pediatric glioblastoma cell lines | Cancer Cell International | Full Te

In the present study we investigated the potential radiosensitizing effect of PCI-24781, a potent pan-histone deacetylase inhibitor (HDACi), ...

RESEARCH Open Access Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental .

Abstract Background: The histone deacetylase inhibitor vorinostat is a candidate radiosensitizer in locally advanced rectal cancer (LARC). Radiosensitivity is critically influenced by hypoxia; hence, ...

Modulation of cellular radiation responses by histone deacetylase inhibitors | Oncoge

and in certain cases apoptosis in cell cultures and in vivo. However, ... Results from recent studies provide direct evidence that a mechanism underlying the synergistic effect of HDAC inhibitors and radiation involves suppression of DNA repair it ...

Abstract B85: In vivo radiosensitizer effect of the HDAC inhibitor S78454 on orthotopic human glioblastoma. | C. Toulas | Request P

Request PDF on ResearchGate | On Mar 1, 2012, C. Toulas and others published Abstract B85: In vivo radiosensitizer effect of the HDAC inhibitor S78454 on orthotopic human glioblastoma. ... Glioblastomas (GBM) are some bad prognosis brain tumors despite a ...

Radiotherapy and Oncology | ICTR-PHE 2012 Conference | ScienceDirect.c

select article 63 IN VIVO RADIOSENSITIZER EFFECT OF THE HDAC INHIBITOR S78454 ON ORTHOTOPIC HUMAN GLIOBLASTOMA ...

Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma .

Background The histone deacetylase inhibitor vorinostat is a candidate radiosensitizer in locally advanced rectal cancer (LARC). ... In vivo, a similar effect of short-term acute hypoxia was observed, as clamped tumors were more resistant to treatment with ...

Cancer Radiosensitizers: Trends in Pharmacological Scienc

of cytotoxic substances by radiolysis of the radiosensitizer, inhibitors of repair of biomolecules, ... Typically, the therapeutic effect of conventional RT is implemented via the indirect action of free radicals that are generated from the radiolysis of The ...

The histone deacetylase inhibitor PCI-24781 as a putative radiosensitizer in pediatric glioblastoma cell lin

In the present study we investigated the potential radiosensitizing effect of PCI-24781, a potent pan-histone deacetylase ... Some in vivo experiments have also been reported in the literature with the objective of investigating the possible mechanisms involved in ...

Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma .

Vorinostat sensitized colorectal carcinoma cells to radiation under hypoxia in vitro and in vivo and improved therapeutic efficacy in combination with capecitabine ...

HDACs and HDAC Inhibitors in Cancer Development and Thera

Abstract Over the last several decades, it has become clear that epigenetic abnormalities may be one of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play a crucial role in cancer development and progression ...

In Vitro and In Vivo Radiosensitizing Effect of Valproic Acid on Fractionated Irradiati

Conclusion Results of this study indicate that a radiosensitizing effect for fractionated radiotherapy of valproic acid for A549 and U87MG tumors in vivo is evident and that it may be more than additive for U87MG tumors. Further exploitation of histone deacetylase ...

Histone deacetylase inhibitor AR‑42 inhibits breast cancer cell growth and demonstrates a synergistic effect in combination with 5‑

Notably, AR‑42 had a synergistic effect on MCF‑7 cells in combination with fluorouracil, which is one of the most commonly used chemotherapeutic agents. In conclusion, ...

Targeting histone deacetylase 4/ubiquitin‐conjugating enzyme 9 impairs DNA repair for radiosensitization of hepatocellular carcinoma cells in .

In vivo radiosensitizing effect of HDAC4 knockdown (shHDAC4) and the treatment with HDACi. Tumors grown (subcutaneously) ... HDAC INHIBITOR ENHANCES IN VIVO RADIOSENSITIVITY OF HCC ORTHOTOPIC XENOGRAFTS COMPARED TO NORMAL ...

Radiosensitization by the Histone Deacetylase Inhibitor PCI-24781 | Clinical Cancer Resear

Purpose: PCI-24781 is a novel broad spectrum histone deacetylase inhibitor that is currently in phase I clinical trials. ... a leukemic cell line that was induced to express the cyclin-dependent kinase inhibitor p16 was resistant to the toxic effect of HDAC). ...

HDAC Inhibitors: A New Radiosensitizer for Non-small-cell Lung Cancer - Lucheng Zhu, Kan Wu, Shenglin Ma, Shirong Zhang, 20

In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas. Neuro-oncol. ... The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells. Cell Death Dis. 2013e810 ...

Comparison of Radiosensitization by HDAC Inhibitors CUDC-101 and SAHA in Pancreatic Cancer Cel

Abstract: Pancreatic cancer has a poor prognosis. New treatment options are urgently required ... (SF2) again showed the more potent effect of CUDC-101 in MIA PaCa-2 and T3M-4. In Su.86.86 at least similar SF2 fractions were achieved with a three-fold lower ...

Valproic Acid Sensitizes Hepatocellular Carcinoma Cells to Proton Therapy by Suppressing NRF2 Activation | Scientific Repor

This prompted us to investigate an effect of HDAC inhibitors that are recently highlighted as a radiosensitizer, on proton RBE. ... In Vitro and In Vivo Radiosensitizing Effect of Valproic Acid on Fractionated Irradiation. Cancer Res Treat 47, 527–533, https://doi.org ...

Comparison of Radiosensitization by HDAC Inhibitors CUDC-101 and SAHA in Pancreatic Cancer Cel

Abstract: Pancreatic cancer has a poor prognosis. New treatment options are urgently required ... (SF2) again showed the more potent effect of CUDC-101 in MIA PaCa-2 and T3M-4. In Su.86.86 at least similar SF2 fractions were achieved with a three-fold lower ...